Testosterone enanthate is a synthetic male hormone (testosterone) that dissolves slowly in the body and has a long-lasting effect. It is commonly used to treat hypogonadism (low testosterone), in hormone therapy for transgender individuals, and for muscle building purposes.
Testosterone enanthate is used to treat low testosterone levels in men. It is also used in hormone therapy for transgender men. It is usually administered by intramuscular or subcutaneous injection every one to four weeks. Side effects of testosterone enanthate include signs of masculinization such as acne, increased hair growth, voice changes, and increased libido. The drug is a synthetic androgen and anabolic steroid and is therefore an agonist of the androgen receptor (AR), which is the biological target of androgens such as testosterone and dihydrotestosterone (DHT). Testosterone enanthate is a testosterone ester and a long-acting testosterone prodrug in the body. Because it is a testosterone prodrug, the testosterone it releases is biologically identical to the body's own hormone, making it useful for producing masculinization and suitable for androgen replacement therapy. Esterase enzymes break the ester bond in testosterone enanthate, releasing free testosterone and enanthic acid through hydrolysis. This process ensures the continuous release of testosterone in the body.
Testosterone enanthate was introduced for medical use in 1954. Along with testosterone cypionate, testosterone undecanoate, and testosterone propionate, it is one of the most commonly used testosterone esters. In addition to its medical use, testosterone enanthate is also used to improve physical appearance and performance.
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