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ready-to-use pen containing solution for injection
The safety and efficacy of NGENLA (somatrogon) was demonstrated in a randomized, open-label, active-controlled Phase 3 study conducted in over 20 countries. In this study, 224 prepubertal, treatment-naïve children with growth hormone deficiency (GHD) were randomized 1:1 to receive NGENLA once-weekly or GENOTROPIN® (somatropin) once-daily. The study met its primary endpoint of NGENLA non-inferiority compared to GENOTROPIN, as measured by annual height velocity at 12 months. NGENLA was generally well tolerated in the study and had a safety profile comparable to GENOTROPIN. Participants had the opportunity to enroll in a global, open-label, multicenter, long-term extension study in which they were able to either continue receiving or switch to NGENLA. Approximately 95% of the patients switched into the open-label extension study and received NGENLA treatment.
An additional Phase 3 study (C0311002) assessed the perception of the treatment burden of once-weekly NGENLA versus once-daily GENOTROPIN among children three to <18 years of age with GHD and their caregivers. This randomized, multicenter, open-label, crossover study included 87 participants who were on stable growth hormone therapy: 43 were randomized to Sequence 1 (12 weeks of treatment with GENOTROPIN followed by 12 weeks of treatment with NGENLA) and 44 were randomized to Sequence 2 (12 weeks of treatment with NGENLA followed by 12 weeks of treatment with GENOTROPIN). The study demonstrated that treatment with NGENLA improved the mean overall Life Interference total score after 12 weeks of treatment compared to GENOTROPIN.
Calculating Ngenla Dosage:
Let’s say you use 6iu daily for Genotropin. 6 iu daily and 42 iu weekly somatropin.
When using Ngenla you will inject 42iu once a week which makes 14mg.
HGH helps maintain, build and repair healthy tissue in the brain and other organs. This hormone may help speed recovery after an injury and repair muscle tissue after exercise. This helps build muscle mass, speed up metabolism and burn fat. HGH is also known to benefit the quality and appearance of the skin.
Benefits of Growth Hormone;
Increases muscle growth
Eliminates muscle breakdown
Reduces body fat
Regulates energy use
Accelerates wound healing
It has a rejuvenating effect
Promotes bone growth and increases growth in young people up to 36 years of age, strengthens bones
Regulates blood sugar levels
Strengthens the immune system
Anti-Aging
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